怀菊花中黄酮类化学成分研究

冯卫生,陈文静, 郑晓珂, 曹彦刚, 弓建红, 李方, 赵璇,王小兰,齐曼, 郭孟焕

中国药学杂志 ›› 2017, Vol. 52 ›› Issue (17) : 1497-1502.

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中国药学杂志 ›› 2017, Vol. 52 ›› Issue (17) : 1497-1502. DOI: 10.11669/cpj.2017.17.005
论著

怀菊花中黄酮类化学成分研究

  • 冯卫生1,2,陈文静1,2, 郑晓珂1,2, 曹彦刚2,3, 弓建红1, 李方1,2, 赵璇1,王小兰1,齐曼1,2, 郭孟焕1,2
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Flavonoids from the flowers of Chrysanthemum morifolium Ramat.

  • FENG Wei-sheng1,2, CHEN Wen-jing1,2, ZHENG Xiao-ke1,2, CAO Yan-gang2,3, GONG Jian-hong1, LI Fang1,2, ZHAO Xuan1, WANG Xiao-lan1, QI Man1,2, GUO Meng-huan1,2
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摘要

目的 对怀菊花的化学成分进行分离和结构鉴定。方法 利用Diaion HP-20、Toyopearl HW-40、Sephadex LH-20、硅胶等柱色谱技术以及制备液相手段进行分离纯化,根据化合物的理化性质和光谱数据鉴定结构。结果 分离并鉴定了20个黄酮类化合物的结构,分别为:木犀草素(1),芹菜素(2),金合欢素(3),香叶木素(4),金合欢素7-O-β-D-葡萄糖葡萄糖苷(5),芹菜素7-O-β-D-葡萄糖葡萄糖苷(6),金合欢素7-O-(6″-O-乙酰基)-β-D-葡萄糖苷(7),圣草酚(8),柚皮素(9),洋艾素(10),5-羟基-6,7,3′,4′-四甲氧基黄酮(11),5,7-羟基-3′,4′-二甲氧基黄酮(12),4′-甲氧基苜蓿素(13),3′,5′-二甲氧基-4′,5,7-三羟基黄酮(14),5,6-二羟基-3,7,3′,4′-四甲氧基黄酮(15),木犀草素7-O-β-D-葡萄糖醛酸苷甲酯(16),二氢槲皮素7-O-β-D-葡萄糖苷(17),圣草酚7-O-β-D-葡萄糖葡萄糖苷(18),槲皮素3-O-β-D-葡萄糖苷(19)和金合欢素7-O-β-6″-(E) -丁烯酰基葡萄糖苷(20)。结论 化合物9~20均为首次从该植物中分离得到。

Abstract

OBJECTIVE To study the chemical constituents in the flowers of Chrysanthemum morifolium Ramat. METHODS The compounds were isolated with Diaion HP-20, Toyopearl HW-40, Sephadex LH-20, silica gel column chromatography and preparative HPLC. The structures of the compounds were identified by physiochemical properties and spectral analysis. RESULTS Twenty compounds were obtained, and their structures were identified as luteolin (1), apigenin (2), acacetin (3), diosmetin (4), acacetin 7-O-β-D-glucoside (5), acacetin 7-O-β-D-glucoside (6), acacetin7-O-(6″-O-acetyl)-β-D-glucoside (7), eriodictyol (8), naringenin (9), artemetin (10), 5-hydroxy-6,7,3′,4′-tetramethoxyflavone (11), 5,7-dihydroxy-3′,4′-dimethoxyflavone (12), 4′-methoxyctricin (13), 3′,5′-dimethoxy-4′,5,7-trihydroxyflavone (14), 5,6-dihydroxy-3,7,3′,4′-tetramethoxyflavone (15), luteolin 7-O-β-D-glucuronide methyle ester (16), dihydroquercetin-7-β-D-glucoside (17), quercetin 3-O-β-D-glucoside(18), quercetin 3-O-β-D-glucoside (19), and acacetin 7-O-β-(6″-(E)-crotonylglucopyranoside) (20). CONCLUSION Compounds 9-20 were isolated for the first time from this plant.

关键词

怀菊花 / 黄酮 / 木犀草素 / 芹菜素 / 金合欢素 / 香叶木素

Key words

Chrysanthemum morifolium Ramat / flavonoids / luteolin / apigenin / acacetin / diosmetin

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冯卫生,陈文静, 郑晓珂, 曹彦刚, 弓建红, 李方, 赵璇,王小兰,齐曼, 郭孟焕. 怀菊花中黄酮类化学成分研究[J]. 中国药学杂志, 2017, 52(17): 1497-1502 https://doi.org/10.11669/cpj.2017.17.005
FENG Wei-sheng, CHEN Wen-jing, ZHENG Xiao-ke, CAO Yan-gang, GONG Jian-hong, LI Fang, ZHAO Xuan, WANG Xiao-lan, QI Man, GUO Meng-huan. Flavonoids from the flowers of Chrysanthemum morifolium Ramat.[J]. Chinese Pharmaceutical Journal, 2017, 52(17): 1497-1502 https://doi.org/10.11669/cpj.2017.17.005
中图分类号: R284   

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基金

中央引导地方科技发展专项:河南省道地大宗药材种质评价及集约化种植与示范
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